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prEN ISO 19040-1
Edition
09/2023
Water quality - Determination of the estrogenic potential of water and waste water - Part 1: Yeast estrogen screen (Saccharomyces cerevisiae) (ISO 19040-1:2018)
Water quality - Determination of the estrogenic potential of water and waste water - Part 1: Yeast estrogen screen (Saccharomyces cerevisiae) (ISO 19040-1:2018)
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Abstract
This document specifies a method for the determination of the estrogenic potential of water and waste water by means of a reporter gene assay with genetically modified yeast strains Saccharomyces cerevisiae. This reporter gene assay is based on the activation of the human estrogen receptor alpha.
This method is applicable to:
— fresh water;
— waste water;
— aqueous extracts and leachates;
— eluates of sediments (fresh water);
— pore water;
— aqueous solutions of single substances or of chemical mixtures;
— drinking water.
The limit of quantification (LOQ) of this method for the direct analysis of water samples is between 8 ng/l and 15 ng/l 17β-estradiol equivalents (EEQ) based on the results of the international interlaboratory trial (see Annex F). The upper threshold of the dynamic range for this test is between 120 ng/l and 160 ng/l 17β-estradiol equivalents (EEQ). Samples showing estrogenic potencies above this threshold have to be diluted for a valid quantification. Extraction and pre-concentration of water samples can prove necessary, if their estrogenic potential is below the given LOQ.
Status
| Draft - Active | |
| If you have any comments on this standard in public inquiry, you can submit them by filling out the commenting form . |
Origin
| Technical Committee : |
| CEN/TC 230 : Water analysis |
Implementation
| start of the vote on the project | 26/05/2022 | date of ratification (dor) | 10/07/2023 | |||
| end of the vote on the project | 18/08/2022 | date of anouncement (doa) | 11/12/2023 | |||
| start of the vote on the final project | 13/04/2023 | date of publication (dop) | 11/03/2024 | |||
| end of the vote on the final project | 08/06/2023 | date of withdrawal (dow) | 11/03/2024 |
|
Publication Official Journal
of the Grand-Duchy of Luxembourg |
|
| Reference |
International Classification for Standards (ICS codes) :
| 13.060.70 : Examination of biological properties of water |
